Results from diffusivity (×10−3 mm2 s−1) measurementsa
| Structure | Method | Controls for HD Gene Carriers (n = 14) | HD Gene Carriers (n = 15) | P Value | Controls for HD Patients (n = 11) | HD Patients (n = 9) | P Value |
|---|---|---|---|---|---|---|---|
| Caudate | Planar ROI | 0.717 ± 0.02 | 0.697 ± 0.03 | .04 | 0.716 ± 0.02 | 0.806 ± 0.04 | <.001 |
| 0.714 (0.677–0.758) | 0.696 (0.637–0.757) | .03 | 0.711 (0.668–0.763) | 0.811 (0.729–0.883) | <.001 | ||
| Putamen | Planar ROI | 0.711 ± 0.02 | 0.714 ± 0.03 | n.s. | 0.701 ± 0.02 | 0.801 ± 0.06 | .002 |
| 0.723 (0.665–0.758) | 0.720 (0.663–0.768) | n.s. | 0.700 (0.661–0.741) | 0.801 (0.679–0.923) | .003 | ||
| Caudate | Volume average | 0.743 ± 0.02 | 0.721 ± 0.02 | .005 | 0.735 ± 0.02 | 0.788 ± 0.04 | .001 |
| 0.748 (0.701–0.785) | 0.723 (0.683–0.758) | .006 | 0.742 (0.697–0.773) | 0.792 (0.708–0.869) | .009 | ||
| Putamen | Volume average | 0.735 ± 0.02 | 0.733 ± 0.02 | n.s. | 0.725 ± 0.02 | 0.809 ± 0.04 | <.001 |
| 0.737 (0.692–0.778) | 0.735 (0.692–0.774) | n.s. | 0.716 (0.689–0.762) | 0.820 (0.727–0.893) | < .001 |
a Values are expressed as mean ± SD (upper row) and median (range, lower row); significance values are for the t test (upper row) and Mann-Whitney U test (lower row).