Volumetric analysis of brain MR Imaging in MPS II Patients
| Variables | All Patients MR Imaging Studies (N = 33), Mean (SD) | Patients with Cognitive Impairment MR Imaging Studies (N = 22), Mean (SD) | Patients with Normal Cognition MR Imaging Studies (N = 11), Mean (SD) | P Valuea |
|---|---|---|---|---|
| Age (years) | 9.0 (5.0) | 9.9 (6.2) | 7.5 (2.37) | .296 |
| ICV (mL) | 1443 (189) | 1464 (201) | 1407 (176) | .96 |
| Brain tissue (mL) | 1242 (173) | 1234 (195) | 1254 (143) | .25 |
| LV (mL) | 54 (48) | 73 (52) | 21 (13) | .046b |
| Brain tissue/ICV | 0.86 (0.012) | 0.84 (0.03) | 0.89 (0.01) | <.001b |
| LV/ICV | 0.04 (0.015) | 0.05 (0.03) | 0.01 (0.01) | .029b |
a P values were comparisons between patients with cognitive impairment and those with normal cognition.
b P values reached statistical significance.