Neuroimaging features comparing lobar versus septopreoptic HPE
| Lobar | Septopreoptic | |
|---|---|---|
| Cortical nonseparation | Basal frontal | Septal and preoptic regions |
| CC | Rostrum and genu absent; anterior body variably present; splenium present | Rostrum absent or hypoplastic; genu hypoplastic; body and splenium present |
| Anterior interhemispheric fissure and falx | Hypoplastic anteriorly | Fairly deep IHF |
| Ventricles | Rudimentary frontal horns; third ventricle formed | Normal or small frontal horns; third ventricle formed |
| Dorsal cyst | Absent | Absent |
| SP | Absent | Present or dysplastic, rarely absent |
| Hypothalamus | Often fused to some degree (83%) | Anterior hypothalamus often fused |
| Cerebral vasculature | Azygous anterior cerebral artery (more anteriorly displaced) | Azygous anterior cerebral artery (more posteriorly placed) |