Table 2:

MR imaging contrast

MR Imaging Contrast AgentExamplesPredominant EffectMR Imaging SensitivityNotes
T1 agentGd-DTPA (magnevist), Gd-DOTA (dotarem), Mn2+ T1++Gd is chelated for toxicity reasons
T2 agentSPIO, USPIO, MION, CLIOT2++++Large range of sizes
CEST, PARACESTAmino acids, sugars; Eu-DOTASaturation transfer++Preclinical stage
Heteronuclei19F, 31PHot spot imaging+Negligible background signal
  • Note:—Plus signs indicate the relative sensitivity of the different contrast mechanisms.