Demographic, clinical, and MR imaging characteristics of patients with different multiple sclerosis phenotypes
| RRMS | SPMS | PPMS | |
|---|---|---|---|
| Mean age in years (SD) | 34.8 (7.5) | 47.8 (9.1) | 50.8 (7.5) |
| Mean disease duration in years (range) | 6.5 (2–17) | 15.5 (3–34) | 10.0 (2–20) |
| Median EDSS score (range) | 1.5 (1.0–4.5) | 6.0 (3.5–7.5) | 6.0 (3.0–8.5) |
| Median T2 lesion load in milliliters (range) | 12.2 (0.4–38.2) | 31.2 (6.1–87.7) | 15.1 (1.7–65.0) |
| Mean brain volume in milliliters (SD) | 1137 (98) | 1074 (91) | 1116 (108) |
Note.—RRMS indicates relapsing-remitting multiple sclerosis; SPMS, secondary progressive multiple sclerosis; PPMS, primary progressive multiple sclerosis; EDSS, Expanded Disability Status Scale.