|NAA| in control subjects and patients in the hippocampus versus other brain regions
| Brain Region | Controls | Temporal Lobe Epilepsy | |
|---|---|---|---|
| Ipsilateral* | Contralateral† | ||
| Hippocampus (PRESS) | 3.63 ± 0.79 | 3.05 ± 0.47 (P < .05) | 3.38 ± 0.62 (P < .01) |
| Hippocampal body (multisection MRS) | 1.06 ± 0.15 | 0.77 ± 0.20 (P < .001) | 0.94 ± 0.28 (P < .01) |
| Temporal operculum (multisection (MRS) | 1.07 ± 0.06 | 0.89 ± 0.15 (P < .001) | 1.08 ± 0.16 (P < .001) |
| Insular cortex (multisection MRS) | 1.13 ± 0.08 | 0.90 ± 0.20 (P < .01) | 1.11 ± 0.17 (P < .0001) |
| Lateral temporal cortex (multisection MRS) | 1.23 ± 0.06 | 0.93 ± 0.16 (P < .001) | 1.14 ± 0.19 (P < .05) |
| Cerebellar hemisphere (multisection MRS) | 1.34 ± 0.18 | 1.38 ± 0.19 (N.S.) | 1.34 ± 0.19 (N.S.) |
| Cerebral hemisphere (multisection MRS) | 1.30 ± 0.09 | 1.20 ± 0.11 (P < .01) | 1.21 ± 0.10 (N.S.) |
Note.—All values are expressed in institutional units as mean ± SD. |NAA| magnitudes between point-resolved spectroscopy (PRESS) and multisection MR spectroscopy (MRS) differ because of differences in technique.
* P values reflect significantly reduced |NAA| in patients compared with |NAA| in control subjects.
† P values reflect significantly reduced |NAA| in the ipsilateral side compared with |NAA| in the contralateral side of patients.