Results of proton MR spectroscopy in parieto-occipital white matter and gray matter
| A: Patients’ last investigations | ||||||||
|---|---|---|---|---|---|---|---|---|
| Patient | No. of Studies | Age Range, year | White Matter Lipid Peak, au | White Matter Metabolites, mmol/L | ||||
| t-NAA | Cr | Cho | Ins | Glx | ||||
| 1 | 3 | 0.8–1 | 5.7 | 9.5 | 4.9 | 2.3 | 3.0 | 11.6 |
| 2 | 5 | 0.4–4 | 3.0 | 9.5 | 4.7 | 1.5 | 4.6 | 9.8 |
| 3 | 2 | 3–5 | 27.8 | 11.1 | 5.4 | 2.4 | 8.1 | 10.5 |
| 4 | 1 | 8 | 23.4 | 11.1 | 6.0 | 2.1 | 5.3 | 13.6 |
| 5 | 1 | 8 | 11.2 | 8.5 | 4.8 | 2.0 | 4.0 | 8.6 |
| 6 | 2 | 5–9 | 15.5 | 10.1 | 6.1 | 1.8 | 5.1 | 13.4 |
| 7 | 2 | 6–9 | 1.9 | 11.3 | 6.1 | 2.1 | 5.8 | 11.3 |
| 8 | 1 | 9 | 21.3 | 9.3 | 5.8 | 2.4 | 6.6 | 10.6 |
| 9 | 4 | 7–10 | 11.5 | 11.4 | 5.2 | 1.9 | 4.0 | 14.3 |
| 10 | 1 | 10 | Present | — | — | — | — | — |
| 11 | 1 | 13 | 11.2 | 9.4 | 4.7 | 1.8 | 5.9 | 8.7 |
| 12 | 3 | 11–14 | 13.6 | 9.9 | 6.3 | 2.1 | 6.0 | 13.0 |
| 13 | 4 | 12–16 | 19.8 | 11.9 | 6.0 | 2.0 | 6.3 | 10.2 |
| 14 | 2 | 17–17 | 20.3 | 10.5 | 6.6 | 1.8 | 6.7 | 16.0 |
| 15 | 3 | 15–17 | 8.6 | 12.7 | 6.8 | 1.9 | 5.4 | 15.3 |
| 16 | 2 | 21–21 | 6.9 | 11.0 | 7.6 | 2.4 | 5.5 | 14.5 |
| 18 | 1 | 45 | 1.6 | 8.9 | 6.0 | 1.8 | 3.6 | 9.8 |
| B: Group means and standard deviations | ||||||
|---|---|---|---|---|---|---|
| Group | Lipid Peak, au | Metabolites, mmol/L | ||||
| t-NAA | Cr | Cho | Ins | Glx | ||
| White matter | ||||||
| Patients (n = 16) | 12.7 (8.1)* | 10.4 (1.2) | 5.8 (0.8)† | 2.0 (0.3)‡ | 5.4 (1.3)§ | 12.0 (2.4) |
| Control subjects (n = 9) | 0.6 (0.6) | 9.6 (0.9) | 5.1 (0.3) | 1.7 (0.3) | 3.5 (1.0) | 12.4 (0.9) |
| Gray matter | ||||||
| Patients (n = 15) | 0.9 (0.8) | 11.2 (1.6) | 7.1 (1.0) | 1.5 (0.3) | 3.9 (1.6) | 17.0 (2.7) |
| Control subjects (n = 9) | 1.1 (0.8) | 11.1 (0.5) | 6.5 (0.5) | 1.4 (0.1) | 4.3 (0.8) | 15.6 (2.0) |
Note.—au = arbitrary units, t-NAA = total NAA (N-acetylaspartate and N-acetylaspartylglutamate), Cr = creatine and creatine phosphate, Cho = free choline and the choline-containing compounds phosphocholine and glycerophosphorylcholine, Ins = myo-inositol, Glx = glutamine and glutamate, dashes = no data available. P values are given when P < .05 for SLS patients compared with healthy control subjects (unpaired two-tailed t test).
* P = .0002.
† P = .02.
‡ P = .005.
§ P = .001.