Comparing two methods of measuring brain parenchymal fraction and their association with clinical and MR imaging variables in 52 patients with multiple sclerosis
| Semiautomated | Automated | |||
|---|---|---|---|---|
| 2D | 3D | 2D | 3D | |
| Third ventricular width | r = −.82, P < .001 | r = −.79, P < .001 | NR | r = −.81, P < .001 |
| Bicaudate ratio | r = −.74, P < .001 | r = −.74, P < .001 | NR | r = −.74, P < .001 |
| T1 hypointense lesion volume | r = −.38, P = .006 | r = −.44, P = .001 | NR | r = −.48, P < .001 |
| FLAIR hyperintense lesion volume | r = −.24, P = .09 | r = −.35, P = .01 | NR | r = −.44, P = .001 |
| EDSS | r = −.44, P < .001 | r = −.47, P < .001 | NR | r = −.33, P = .008 |
| Disease duration | r = −.50, P < .001 | r = −.39, P = .002 | NR | r = −.53, P < .001 |