Subject demographics, CAG repeat size, and test scores
| Measure | Participants | ||
|---|---|---|---|
| Far | Close | Control | |
| Age (years)* | 33.0 (5.0) | 41.1 (5.9) | 38.0 (6.1) |
| Education (years) | 14.6 (2.4) | 14.1 (1.7) | 14.9 (1.9) |
| Sex (M/F) | (2/5) | (4/3) | (2/5) |
| CAG repeat size† | 41.3 (2.1) | 44.2 (2.5) | NA |
| Estimated years to symptom onset‡ | 24.6 (7.9) | 8.6 (2.5) | NA |
| UHDRS motor score | 0.7 (1.0) | 1.4 (0.9) | NA |
| UHDRS verbal fluency | 39.9 (11.7) | 32.9 (8.7) | 39.4 (6.4) |
| UHDRS symbol-digit | 57.3 (10.0) | 44.9 (8.8) | 52.4 (10.9) |
| UHDRS stroop interference | 50.9 (13.1) | 37.1 (12.2) | 44.0 (7.5) |
Note.—NA indicates not applicable; UHDRS, Unified HD Rating Scale. Data are the mean (standard deviation).
* Close participants were significantly older than far participants (P < .05).
† Close participants had a significantly longer CAG repeat size than that of far participants (P < .05).
‡ In the close group, onset was predicted significantly earlier than in the far group (P < .001).