TABLE 2:

Univariate correlations between clinical and MR imaging measures of MS disease activity

Variable 1^*	Variable 2^*	All Patients (n = 239)	Placebo Group (n = 120)	GA Group (n = 119)
Pre-study relapses	On-trial relapses	0.21 (.001)	0.19 (.04)	0.25 (.006)
Pre-study relapses	Baseline EL	0.10	0.09	0.11
Pre-study relapses	On-trial EL	0.15 (.02)	0.14	0.20 (.03)
Pre-study relapses	On-trial new T2 lesions	0.19 (.003)	0.15	0.27 (.003)
On-trial relapses	Baseline EL	0.25 (<.001)	0.30 (.001)	0.22 (.02)
On-trial relapses	On-trial EL	0.30 (<.001)	0.36 (<.001)	0.21 (.02)
On-trial relapses	On-trial new T2 lesions	0.32 (<.001)	0.34 (<.001)	0.25 (.006)
Baseline EL	On-trial EL	0.64 (<.001)	0.66 (<.001)	0.65 (<.001)
On-trial EL	On-trial new T2 lesions	0.88 (<.001)	0.90 (<.001)	0.84 (<.001)

Note.—Values are the Spearman rank correlation coefficients. Data in parentheses are P values ≤.05.
* Pre-study relapses indicate the number of relapses during the 2 years prior to the study period; baseline EL, the number of Gd-enhancing lesions on the images obtained at study entry; and on-trial EL, the total number of Gd-enhancing lesions during the 9 months of the study.