Patient (No.) | Age (y) | Age (y) at Treatment | Interval (y) | Total CRT Dose (Gy) | Chemo | WM | VI | FA ▵ (%) | Postoperative Complications | Deterioration in School Performance |
---|---|---|---|---|---|---|---|---|---|---|
1 | 19 | 13 | 6 | 54 | babyPOG | 0 | 0.31 | 19.2 | None | Moderate |
2 | 16 | 14 | 2 | 54.6 | CCV | 0 | 0.22 | 21.9 | None | Moderate |
3 | 13 | 12 | 1 | 50.4 | CCV | 0 | 0.27 | 9.9 | None | Mild |
4 | 13 | 7 | 6 | 54 | babyPOG | 0 | 0.24 | 11.6 | Cerebellar mutism | Moderate |
5 | 10 | 4 | 6 | 54 | babyPOG | 3 | 0.33 | 46.2 | Hydrocephalus, shunt infection | Severe |
6 | 9 | 3 | 6 | 54 | babyPOG | 1 | 0.31 | 15.8 | None | Moderate |
7 | 7 | 5 | 2 | 50.4 | babyPOG | 0 | 0.25 | 21.1 | None | Moderate |
8 | 7 | 5 | 2 | 54 | CCV | 0 | 0.24 | 4 | Bleeding during surgery | Mild |
9 | 3 | 3 | 1 | 50.4 | babyPOG | 2 | 0.30 | 18.2 | Cerebellar mutism | Moderate* |
Note.—CRT signifies cranial radiation therapy; Chemo, chemotherapy regimen; WM, white matter grade determined by MR imaging (4-point scale [see Methods]); VI, ventricular index (maximum width of the frontal horns divided by the maximum internal skull diameter); FA ▵ (%), percentage of reduction in the supratentorial white matter fractional anisotropy of patients versus controls.
* Delayed developmental milestones.