TABLE 1:

Clinical, MR, and fractional anisotropy data in nine medulloblastoma survivors

Patient (No.)Age (y)Age (y) at TreatmentInterval (y)Total CRT Dose (Gy)ChemoWMVIFA ▵ (%)Postoperative ComplicationsDeterioration in School Performance
11913654babyPOG00.3119.2NoneModerate
21614254.6CCV00.2221.9NoneModerate
31312150.4CCV00.279.9NoneMild
4137654babyPOG00.2411.6Cerebellar mutismModerate
5104654babyPOG30.3346.2Hydrocephalus, shunt infectionSevere
693654babyPOG10.3115.8NoneModerate
775250.4babyPOG00.2521.1NoneModerate
875254CCV00.244Bleeding during surgeryMild
933150.4babyPOG20.3018.2Cerebellar mutismModerate*
  • Note.—CRT signifies cranial radiation therapy; Chemo, chemotherapy regimen; WM, white matter grade determined by MR imaging (4-point scale [see Methods]); VI, ventricular index (maximum width of the frontal horns divided by the maximum internal skull diameter); FA ▵ (%), percentage of reduction in the supratentorial white matter fractional anisotropy of patients versus controls.

  • * Delayed developmental milestones.