Alginate, angiographic scores, and neointima thickness
| Group | Aneurysm Type | Embolic Agent | Number of Aneurysms | Median Angiographic Scores | Neointima Thickness (μm) | |
|---|---|---|---|---|---|---|
| T0 | T3 weeks | |||||
| I | Canine lateral wall | Alginate + 125I/TGF-β | 16 | |||
| II | Canine lateral wall | Gelfoam sponge | 4 | 3 | 3 | 94 ± 90 |
| Canine lateral wall | Sponge + alginate | 4 | 1 | 1 | >1000 | |
| III | Porcine aneurysms | Alginate | 12 | 2.5 | 1 | >1000 |
| IV | Canine lateral wall | Alginate | 4 | 2 | 2.5 | NA |
| Canine bifurcation | Alginate | 4 | 2 | 0 | NA | |
| V | Alginate | 8 | 3 | 2 | 238 ± 226 | |
| VI | Canine lateral wall | Alginate block | 10 | 3* | 1* | 255 ± 142 |
| Canine lateral wall | Alginate block + PDGF-BB | 5 | 3 | 0 | 565 ± 457 | |
| Canine lateral wall | Alginate block + TGF-β1 | 5 | 3 | 2 | 680 ± 543 | |
Note.—125 I indicates iodine-125; TGF, transforming growth factor; PDGF, platelet-derived growth factor.
* P = .039