TABLE 2:

Metabolite ratios

Individual	Metabolite Levels Relative to Gray Matter			Metabolite Ratios
Individual	Cho	Cr	NAA	NAA/Cho	NAA/Cr	Cho/Cr
A. Frontal white matter
Patient 1	1.17	1.19	0.84	1.16	1.63	1.41
Patient 2	1.28	1.01	1.02	1.62	2.63	1.63
Patient 3	1.68	0.95	0.87	1.27	2.32	1.83
Control subject 1	1.64	1.00	0.81	1.09	2.17	2.00
Control subject 2	1.51	0.92	0.94	1.26	2.57	2.03
Control subject 3	1.14	0.61	0.85	1.89	4.17	2.21
B. Centrum semiovale
Patient 1	1.38	1.11	0.74	0.87	1.55	1.79
Patient 2	1.28	0.95	0.89	1.42	2.43	1.71
Patient 3	1.61	1.02	0.96	1.46	2.38	1.63
Control subject 1	1.35	0.81	0.82	1.34	2.71	2.03
Control subject 2	1.38	0.85	0.99	1.46	2.90	1.99
Control subject 3	1.55	0.85	0.99	1.61	3.46	2.15
C: Parietal white matter
Patient 1	1.31	1.03	0.61	0.76	1.37	1.81
Patient 2	1.13	0.97	0.93	1.69	2.50	1.48
Patient 3	1.65	1.03	0.81	1.20	1.98	1.66
Control subject 1	1.42	0.92	0.84	1.29	2.42	1.87
Control subject 2	1.42	0.84	0.96	1.37	2.84	2.07
Control subject 3	1.45	0.66	0.84	1.46	3.80	2.60
D: Parieto-occipital gray matter^*
Patient 1	NA	NA	NA	1.61	2.31	1.43
Patient 2	NA	NA	NA	2.03	2.60	1.28
Patient 3	NA	NA	NA	2.44	2.52	1.04
Control subject 1	NA	NA	NA	2.19	2.67	1.22
Control subject 2	NA	NA	NA	2.03	2.50	1.23
Control subject 3	NA	NA	NA	2.52	2.99	1.18

Note.—Patient 1 was aged 2 years 5 months; patient 2, 3 years, 8 months; patient 3, 7 years, 6 months; control subject 1, 1 year, 9 months; control subject 2, 3 years, 2 months; and control subject 3, 7 years, 0 months.
* NA indicates not applicable.