Diseases involving bilateral middle cerebellar peduncles
| Diagnosis (no.) | Age/sex | Pontine Lesions | Cbll Lesions | Other Lesions |
|---|---|---|---|---|
| Degenerative diseases (11) | ||||
| sOPCA (8) | 47, 50, 53, 55/M,61, 68, 71, 72/F | Cross sign, atrophy | Atrophy | Atrophy of basal ganglia with linear hyperintensity at lateral margins (3) |
| SCA2 (1) | 42/M | Cross sign, atrophy | Atrophy | (-) |
| SCA6 (1) | 48/F | Cross sign, atrophy | Atrophy | (-) |
| Shy-Drager synd (1) | 57/M | Linear lesion on midline | (-) | (-) |
| Metabolic diseases (6) | ||||
| Adrenoleukodystrophy (2) | 4, 38/M | Lesions along pyramidal tracts (1), heterogeneous lesions (1), | WML (2) | Large symmetrical parieto-occipial WML (1), lesions along pyramidal tracts (1) |
| Wilson disease (2) | 24/M, 34/F | Several small lesions (2), atrophy (1) | Mild atrophy (1) | Midbrain (tegmentum) and basal ggl lesions (2) and thalamic lesions (1) |
| Alcoholic liver cirrhosis (1) | 51/M | (-) | Mild atrophy | T1 hyperintensity at globi pallidi |
| Hypoglycemic coma (1) | 52/F | Lesions along pyramidal tracts on DWI | (-) | Hyperintensity lesions along pyramidal tracts on T2WI and DWI |
| Neoplasms (3) | ||||
| Diffuse infiltrating ML (1) | 55/F | Heterogeneous lesions, enlargement | Diffuse WML | Whole corpus callosum and diffuse cbr WML |
| Brain stem glioma (1) | 74/M | Ring-enhancement, enlargement | (-) | Tumor extension into medulla oblongata and midbrain |
| Meningeal carcinomatosis (1) | 77/F | Multiple lacunar infarcts | Enhancement in fissures | Leptomeningeal enhancement, multiple lacunar infarction, mild hydrocephalus |
| Cerebrovascular disease, hypertensive and its related encephalopathies (3) | ||||
| AICA infarction (1) | 57/M | Lacunar infarcts | Infarction in AICA distribution | Multiple lacunar infarction |
| Hypertensive encephalopathy (1) | 51/F | Heterogeneous lesion, enlargement | Diffuse WML, swelling | Midbrain, basal ganglia, thalamus, bilateral hippocampus, periventricular WML |
| Cyclosporin-A encephalopathy (1) | 16/F | A few punctate lesions | Diffuse swelling | Small parietal WML |
| Inflammatory & demyelinating diseases (4) | ||||
| Multiple sclerosis (1) | 17/F | Small tegmental lesions | Mild atrophy | Small lesions in corpus callosum, small oval periventricular WML |
| ADEM (1) | 38/M | Heterogeneous lesions | (-) | Multiple subcortical WML |
| Behcet disease (1) | 66/F | Subtle heterogeneous lesions | (-) | Non-specific punctate WML |
| HIV encephalopathy (1) | 31/M | Diffuse hyperintensity | (-) | Frontal WML, mild brain atropohy |
| Total (27) | mean age, 48.5 y |
Note.—ADEM, acute disseminated encephalomyelitis; cbll, cerebellar; cbr, cerebral; DWI, diffusion-weighted imaging; ggl, ganglia; HIV, human immunodeficiency virus; ML, malignant lymphoma; SCA, spinocerebellar ataxia; sOPCA, sporadic olivopontocerebellar atrophy; T2WI, T2-weighted imaging; WML, white matter lesions.