Table 4:

Regression coefficients, P values, and goodness of fit measures of the relationships of neuropsychologic test scores with WM tract mean diffusivity and FA values, adjusted for subject age and clinical disability

Neuropsychologic TestDT MR VariableβPapFDRbPartial R2Overall R2
TMT-ACC MD0.008.03.130.200.76
R ILF MD0.007.05.130.180.74
CC FA−0.013.01.040.250.81
R CST FA−0.016.02.040.210.78
L CST FA−0.016.02.040.210.78
R cingulum FA−0.011.046.070.180.74
R IFOF FA−0.015.01.040.260.83
L IFOF FA−0.020.003.020.300.87
R ILF FA−0.020.003.020.300.86
L ILF FA−0.015.01.040.240.80
R uncinate FA−0.015.02.040.220.78
TMT-BCC MD0.01.04.150.230.70
CC FA−0.017.01.0510.300.77
R cingulum FA−0.014.047.070.220.69
L cingulum FA−0.016.04.070.230.70
R IFOF FA−0.021.002.010.380.85
L IFOF FA−0.029<.001.0010.460.93
R ILF FA−0.023.01.0510.290.76
R uncinate FA−0.018.03.070.250.72
TMT-BAR IFOF FA−0.029.01.090.360.72
L IFOF FA−0.039.004.0490.430.79
Stroop testCC FA−0.014.03.220.360.41
R IFOF FA−0.011.048.220.320.37
R ILF FA−0.018.02.220.410.46
WCST, global scoreR IFOF MD−0.007.03.110.310.64
L IFOF MD−0.007.02.110.340.67
R ILF MD−0.007.03.110.320.65
L ILF MD−0.008.02.110.350.68
R IFOF FA0.016.02.320.460.53
Phonemic fluencyL cingulum FA0.008.01.200.360.47
Rey's words, immediate recallFornix MD−0.001.04.320.160.67
Fornix FA0.005.004.0550.270.77
Rey's words, delayed recallFornix MD−0.002.03.430.500.62
Rey's figure copyL uncinate FA0.005.04.510.320.73

  • Note:—β, regression coefficient; partial R2, proportion of variability accounted for by the given DT MRI variable; overall R2, proportion of variability accounted for by the full statistical model; TMT, Trail-Making Test; WCST, Wisconsin Card Sorting Test; CC, corpos callosum; CST, corticospinal tract.

  • ↵a P values according to the multivariate linear models, adjusting for subject's age and ALSFRS-r.

  • ↵b P values also were adjusted for multiple comparisons controlling the false discovery rate.