Table 3:

Putative theories to explain elevated ICP in PTCa

Proximal EtiologyResult
Increased interstitial fluid (ISF) volumeIncreased cerebral volume
Increased blood volume
Increased tissue volume
Increased CSF production rateIncreased CSF volume
Increased CSF outflow resistance
Loss of cerebral autoregulationIncreased cerebral arterial pressure
Increased cerebral venous pressureIncreased venous blood volume and increased ISF
Reduced CSF outflow and increased CSF volume
  • a (Adapted from Walker.10)