Demographic and endocrine dataa
| Lean | Obese | P | |
|---|---|---|---|
| Sample size | 31 | 48 | – |
| Female | 55% (17) | 69% (33) | .21 |
| Age (yr) | 17.1 ± 1.6 | 17.9 ± 1.5 | .018 |
| SES categoryb | 2.5 ± 1.5 | 2.0 ± 1.1 | .154 |
| BMI (kg/m2) | 21.5 ± 2.3 | 37.7 ± 5.9 | <.0001 |
| Waist/height ratio | 0.85 ± 0.05 | 0.95 ± 0.06 | <.0001 |
| MAP | 75.9 ± 7.72 | 82.6 ± 8.30 | .001 |
| Triglycerides (mg/dL) | 71.6 ± 31.7 | 83.7 ± 35.4 | .123 |
| Cholesterol (mg/dL) | 155.7 ± 28.3 | 161.0 ± 23.6 | .382 |
| HDL (mg/dL) | 52.7 ± 10.7 | 43.4 ± 8.9 | <.0001 |
| LDL (mg/dL) | 88.8 ± 25.2 | 101.0 ± 20.3 | .023 |
| HOMA-IR | 1.47 ± 0.86 | 3.78 ± 2.66 | <.0001 |
| Fasting insulin (μIU/L) | 7.96 ± 4.16 | 19.99 ± 14.01 | <.0001 |
| Fasting glucose (mg/dL) | 74.6 ± 7.7 | 76.5 ± 8.2 | .310 |
| Brain tissue volume (mL) | 1164 ± 108 | 1144 ± 141 | .510 |
| Intracranial vault volume (mL) | 1194 ± 111 | 1183 ± 144 | .728 |
| CSF volume (mL) | 29.7 ± 11.1 | 38.7 ± 20.2 | .012 |