Distinctive features of the 2 main groups of HGG mouse models
| Features |
|---|
| Endogenous models (GEMMs and nontargeted mutagenesis/carcinogenesis) |
| Unpredictable latency periods, growth curves, tumor location, and morphology; implies regular screening for tumor detection and longitudinal monitoring for progression; more physiologic and best representing human disease |
| Exogenous models or xenografts |
| Predictable and reproducible, high tumor take; best for high throughput preclinical trials; less physiologic and less representative of the actual human condition |