Table 2:

Comparison of neuroimaging features in NBIA

Disorder	Iron Deposition	White Matter Involvement	Other Findings
PKAN	Globus pallidus, substantia nigra (mild)	No	Eye-of-the-tiger sign
PLAN	Globus pallidus,^{^a} substantia nigra^{^a}	Mild	Moderate cerebellar atrophy
NFT	“Patchy” globus pallidus, putamen, caudate, dentate, thalamus	Mild, moderate	Cystic cavitation, mild cerebral, cerebellar atrophy
ACP	Globus pallidus, putamen, caudate, thalamus, red nucleus, dentate	Moderate, severe	Mild cerebellar atrophy
FAHN	Globus pallidus, substantia nigra^{^b}	Moderate	Pontocerebellar atrophy
KRS	Globus pallidus, putamen, caudate^{^b}		Severe cerebral, cerebellar, brain stem atrophy
WSS	Globus pallidus^{^b}	Severe, confluent
SENDA	Substantia nigra, globus pallidus	Occasional	Midbrain T1 hyperintensity

↵a Inconsistent finding.
↵b Numbers of genetically confirmed cases are still too small to determine the frequency of iron deposition.