WMA assessment at conventional MRI
| Characteristics | Score 1 | Score 2 | Score 3 |
|---|---|---|---|
| White matter signal abnormality | Normal | Focal regions | Multiple regions |
| (<2 regions per hemisphere) | (>2 regions) | ||
| 34/70 (48.6%) | 15/70 (21.4%) | 21/70 (30.0%) | |
| White matter volume loss | Normal | Mild reduction with increased ventricular size (EI = 0.3–0.36) | Marked reduction with increased ventricular size (EI > 0.36) |
| 61/70 (87.1%) | 9/70 (12.9%) | 0/70 (0%) | |
| Cystic abnormalities | Normal | <2-mm single focal cyst | Multiple cysts or a single larger (>2 mm) focal cyst |
| 66/70 (94.3%) | 0/70 (0%) | 4/70 (5.7%) | |
| Ventricular dilation | Normal | Mild-moderate enlargement of the frontal, temporal, and occipital horns | More global enlargement of the frontal, temporal, and occipital horns |
| 57/70 (81.4%) | 12/70 (17.2%) | 1/70 (1.4%) | |
| Thinning of the corpus callosum | Normal | Focal thinning in the corpus callosum | Global thinning across the entire corpus callosum |
| 54/70 (77.2%) | 15/70 (21.4%) | 1/70 (1.4%) |
Note:—EI indicates Evans Index.