Table 1:

Geneontology analysis of proteins up-regulated in the dome of densely packed aneurysms compared with loosely packed aneurysms at 2 weeks following coil embolization

Biologic ProcessNumber of Proteins Up-RegulatedProtein Symbol
Generation of precursor metabolites and energy17ALDOA, ALDOC, ATP5A1, ETFA, GNAS, IDH3B, IDH1, MDH2, NDUFA10, PDHA1, PPP1CA, PYGL, UQCRC2, SUCLG1, SUCLG2, ACAA1, ATP6V1C1
Oxidation reduction15ACADM, AKR1B10, AKR1C4, CBR1, ETFA, GPD1, IDH3B, IDH1, IVD, KCNAB2, MDH2, NDUFA10, PDHA1, UQCRC2
Response to organic substance14GOT2, ALDOC, CA2, CTSC, CORO1A, CRYAB, AHSG, GNAS, IDH1, PRKACA, MAPK1, PPP2CA, RBM4, THBS1,
Protein localization13GNAS, LMAN2, MAPK1, MVP, MYO1C, HSPG2, PPT1, SEC61A1, SELENBP1, SCAMP2, SNX5, TOMM40, VPS26A
Response to wounding12SERPINC1, CRP, VCAN, F13A1, AHSG, FN1, GNA13, GNAQ, ITGB2, MGLL, PLG, THBS1
Cell adhesion12AEBP1, TGFBI, CORO1A, VCAN, ECM2, FN1, ITGB2, HSPG2, PGM5, RPSA, SPON1, THBS1
Protein transport12GNAS, LMAN2, MAPK1, MVP, MYO1C, PPT1, SEC61A1, SELENBP1, SCAMP2, SNX5, TOMM40, VPS26A
Response to endogenous stimulus10ALDOC, CA2, CRYAB, AHSG, GNAS, IDH1, PRKACA, MAPK1, RBM4, THBS1
Glucose metabolic process9ALDOA, ALDOC, CRYAB, GPD1, MDH2, PDHA1, PGM5, PPP1CA, PYGL
Response to hormone stimulus9CA2, CRYAB, AHSG, GNAS, IDH1, PRKACA, MAPK1, RBM4, THBS1
  • Note:—Top 10 biologic process with descending protein count and Expression Analysis Systematic Explorer (EASE) score, P < 0.05.