Change of neurologic scores during a median of 12 months
| Score | No. | Baseline | Follow-Upa | P Valueb | Split Thresholdc | Progression | Nonprogression |
|---|---|---|---|---|---|---|---|
| EDSS (median) (range) | 44 | 2.0 (0–5.5) | 2.0 (0–5.5) | 0.950 | ≥0.5c | 9 | 35 |
| MSFC (mean) (SD) | 38 | 0.550 (0.415) | 0.549 (0.475) | 0.969 | <−0.047 | 13 | 25 |
| TWT (mean) (SD)d | 39 | −0.431 (0.082) | −0.412 (0.098) | 0.105 | >0.013 | 16 | 23 |
| 9-HPT (mean) (SD)e | 40 | 0.780 (0.735) | 0.736 (0.837) | 0.382 | <−0.113 | 15 | 25 |
| PASAT (mean)f | 39 | 0.460 (0.693) | 0.531 (0.800) | 0.414 | <−0.101 | 8 | 31 |
↵a Annualized values for MSFC, raw values for EDSS (for details see “Materials and Methods”).
↵b Two-sided Wilcoxon signed rank test (EDSS) and paired Studentt test (MSFC, annualized follow-up values), respectively.
↵c See “Materials and Methods” section for details on threshold definition.
↵d TWT.
↵e 9-HPT.
↵f PASAT.