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Celite, kaolin, and glass are activators used to measure ACT that yield different results
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Celite-ACT is significantly longer than kaolin ACT
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ACT values from a particular device are reproducible and correlate with anti-Xa values
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ACT is device-specific even if the activator used is the same
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ACT following administration of heparin varies based on heparin-dependent (heparin responsiveness/resistance) and heparin-independent (hemodilution, hypothermia, platelet count, race, and so forth) factors
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LMWH anticoagulation can be monitored by ACT
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Hemonox-CT is a more specific POC test for LMWH
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Concomitant use of abciximab increases ACT; eptifibatide leads to less marked changes in ACT
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Concomitant aprotinin administration affects Celite-ACT more than kaolin-ACT
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Heparin concentrations are divided into high (>1 U/mL) and low (<1 U/mL)
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Kaolin-based ACT is less accurate in low-intensity anticoagulation
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Glass beads in a plastic tube are more effective in moderate heparin concentrations
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Hemochron produces lower ACT values than the Automated Coagulation Timer System (previously HemoTec)
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The corresponding anti-Xa values are needed to establish a therapeutic ACT range for a particular device
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Institutions should establish their individual therapeutic ACT ranges
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