Table 4:

Any clinical events during/immediately after or in the follow-up period

Adverse EventsNo. of PatientsPermanent Morbidity/Mortality
Due to medication
    Intracranial hemorrhage21
    Aplastic anemiaa1No
    Hematuria (requiring change in medical treatment)1No
    GI bleeding (including the FU period)2No
Associated with intervention
    Deep vein thrombosis1No
    Retroperitoneal hematomab3No
Associated with aneurysm treatment
    Due to mass effectc41
    SAH (aneurysm rupture)1Nod
In relation to PED
    Perioperative thromboembolic event41) Mortality (jailed PCA occlusion)
3) Symptoms resolved totallye
    In-stent stenosisf8No
        Mild5 No intervention
        Severe3 PTAs performedg
    Ischemic event in the FU period1e
Total27 (14.1%)e2 (1%)/1 (0.5%)
  • Note:—FU indicates follow-up; GI, gastrointestinal; PTA, percutaneous transarterial angioplasty.

  • a Occurred in the patient who had resistance to clopidogrel and was on ticlopidine.

  • b Included in the group of complications that are attributed to intervention, but antithrombocytic medication may also have contributed.

  • c Any new symptom or increase in the findings are taken into consideration; 3 had deteriorating vision loss, of whom 2 also had visual field defects. In 2 patients, the symptoms regressed to their preoperative degree in the follow-up and caused permanent additional morbidity in 1. The remaining patient had symptoms due to mass effect on the brain stem, aggravated after the treatment, but resolved in 4 weeks' time.

  • d This patient had subarachnoid hemorrhage 4 months after the treatment; imaging still showed filling of the aneurysm despite significant decrease. Initially she had had hemiparesis, but this resolved totally.

  • e One patient had an ischemic attack in the postoperative 4 months after he discontinued clopidogrel without consulting his doctor. The patient was medicated with IV heparin, and clopidogrel was loaded again. The symptom of monoparesis resolved totally. The same patient woke up from the general anesthesia with monoparesis but immediately became asymptomatic after volume loading and raising the blood pressure.

  • f Mild refers to any intimal thickening causing stenosis <50%. Severe refers to stenosis ≥50%.

  • g In 2 patients, stenosis was discovered in the control angiography but PTA was performed because the stenosis was considered significant (>70%). The remaining patient had attacks of dysphasia which resolved after PTA, with no permanent morbidity.