Baseline characteristics
| Variable | RCSN3 2003–2008 | OSA 2002/03 and 2004/05 | Comparison of all Patients from RCSN versus OSA (P value) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| All (n = 9872) | GFR ≥30 (n = 9393) | GFR <30 (n = 479) | P Value | All (n = 2544) | GFR ≥30 (n = 2411) | GFR <30 (n = 133 ) | P Value | ||
| Age | |||||||||
| Median (IQR) (yr) | 75 (65–83) | 74 (64–82) | 82 (77–88) | <.0001 | 77 (68–83) | 76 (67–83) | 82 (77–87) | <.0001 | <.0001 |
| ≥65 yr (No.) (%) | 7389 (74.8) | 6936 (73.8) | 453 (94.6) | <.0001 | 2066 (81.2) | 1936 (80.3) | 130 (97.7) | <.0001 | <.0001 |
| No. of women (No.) (%) | 4827 (48.9) | 4827 (48.9) | 294 (61.4) | <.0001 | 1258 (49.4) | 1177 (48.8) | 81 (60.9) | .007 | .62 |
| Stroke type (No.) (%) | <.0001 | .005 | <.0001 | ||||||
| Ischemic stroke | 5496 (55.7) | 5175 (55.1) | 321 (67.0) | 1101 (43.3) | 1026 (42.6) | 75 (56.4) | |||
| TIA | 3307 (33.5) | 3176 (33.8) | 131 (27.3) | 1251 (49.2) | 1198 (49.7) | 53 (39.8) | |||
| ICH | 1069 (10.8) | 1042 (11.1) | 27 (5.6) | 192 (7.5) | 187 (7.8) | ≤5 (≤3.8) | |||
| Diabetes mellitus (No.) (%) | 2178 (22.1) | 2033 (21.6) | 145 (30.3) | <.0001 | 549 (21.6) | 497 (20.6) | 52 (39.1) | <.0001 | .60 |
| Hypertension (No.) (%) | 6552 (66.4) | 6159 (65.6) | 393 (82.0) | <.0001 | 1512 (59.4) | 1417 (58.8) | 95 (71.4) | .004 | <.0001 |
| Hyperlipidemia (No.) (%) | 3478 (35.2) | 3298 (35.1) | 180 (37.6) | .27 | 718 (28.2) | 684 (28.4) | 34 (25.6) | .48 | <.0001 |
| Peripheral vascular disease (No.) (%) | 529 (5.4) | 483 (5.1) | 46 (9.6) | <.0001 | 105 (4.1) | 92 (3.8) | 13 (9.8) | .0008 | .01 |
| Current smoking (No.) (%) | 1481 (15.0) | 1450 (15.4) | 31 (6.5) | <.0001 | 313 (12.3) | 304 (12.6) | 9 (6.8) | .046 | .0006 |
| Previous myocardial infarction (No.) (%) | 1492 (15.1) | 1382 (14.7) | 110 (23.0) | <.0001 | 381 (15.0) | 343 (14.2) | 38 (28.6) | <.0001 | .86 |
| Previous stroke or TIA (No.) (%) | 3357 (34.0) | 3149 (33.5) | 208 (43.4) | <.0001 | 979 (38.5) | 919 (38.1) | 60 (45.1) | 011 | <.0001 |
| Preadmission medications (No.) (%): | |||||||||
| Metformin | 1038 (10.5) | 1006 (10.7) | 32 (6.7) | .005 | 253 (9.9) | 237 (9.8) | 16 (12.0) | .41 | .40 |
| Insulin | 414 (4.2) | 368 (3.9) | 46 (9.6) | <.0001 | 99 (3.9) | 84 (3.5) | 15 (11.3) | <.0001 | .49 |
Note:—ICH indicates intracerebral hemorrhage.