HC (n = 65) | CIS (n = 42) | P value | |
---|---|---|---|
Female (n [%]) | 41 (63.1) | 31 (73.8) | .295 |
Age in years (mean [SD]) | 42.8 (14) | 40.1 (10.4) | .288 |
Age at onset in years (mean [SD]) | NA | 38.8 (10.6) | NA |
Disease duration in years (mean [SD] median) | NA | 1.2 (1.3) 1 | NA |
EDSS (median [range]) | NA | 1.0 (0–2.5) | NA |
Presence of disease-modifying therapy | NA | 22 (52.4%) | NA |
Type of onset (n [%]) | |||
Polysymptomatic | NA | 7 (16.7%) | |
Monosymptomatic | NA | 35 (83.3%) | |
Spinal cord syndrome | 23 (65.7%) | ||
Optic neuritis | 8 (22.9%) | ||
Brain stem/cerebellar | 4 (11.4%) | ||
Gd lesion number (mean [SD]) | NA | .4 (1.1) | NA |
T2 lesion number (mean [SD]) | NA | 12.3 (15.3) | NA |
1–4 lesions (n [%]) | 15 (35.7%) | ||
5–8 lesions (n [%]) | 6 (14.3%) | ||
≥9 lesions (n [%]) | 18 (42.9%) | ||
Gd lesion volume (mean [SD]) | NA | .08 (.3) | NA |
T2 lesion volume (mean [SD]) | NA | 1.7 (2.6) | NA |
NGMV (mean [SD]) | 822.3 (63.2) | 821.5 (58.2) | .953 |
NWMV (mean [SD]) | 775.3 (63.3) | 760.6 (40.2) | .154 |
NBV (mean [SD]) | 1592.9 (99.6) | 1583 (56.5) | .521 |
NLVV (mean [SD]) | 27.9 (13.7) | 32.6 (18.9) | .145 |
Note:—All lesion and brain volumes are expressed in milliliters. Of the 42 patients with CIS, 33 presented with brain T2 lesions and 9 with spinal cord T2 lesions. Differences between the groups were tested using the χ2 (gender) test and Student t test. NA indicates not available.