Table 1:

Demographic, clinical, and MRI characteristics of the study groups

HC (n = 65)CIS (n = 42)P value
Female (n [%])41 (63.1)31 (73.8).295
Age in years (mean [SD])42.8 (14)40.1 (10.4).288
Age at onset in years (mean [SD])NA38.8 (10.6)NA
Disease duration in years (mean [SD] median)NA1.2 (1.3) 1NA
EDSS (median [range])NA1.0 (0–2.5)NA
Presence of disease-modifying therapyNA22 (52.4%)NA
Type of onset (n [%])
PolysymptomaticNA7 (16.7%)
MonosymptomaticNA35 (83.3%)
    Spinal cord syndrome23 (65.7%)
    Optic neuritis8 (22.9%)
    Brain stem/cerebellar4 (11.4%)
Gd lesion number (mean [SD])NA.4 (1.1)NA
T2 lesion number (mean [SD])NA12.3 (15.3)NA
    1–4 lesions (n [%])15 (35.7%)
    5–8 lesions (n [%])6 (14.3%)
    ≥9 lesions (n [%])18 (42.9%)
Gd lesion volume (mean [SD])NA.08 (.3)NA
T2 lesion volume (mean [SD])NA1.7 (2.6)NA
NGMV (mean [SD])822.3 (63.2)821.5 (58.2).953
NWMV (mean [SD])775.3 (63.3)760.6 (40.2).154
NBV (mean [SD])1592.9 (99.6)1583 (56.5).521
NLVV (mean [SD])27.9 (13.7)32.6 (18.9).145
  • Note:—All lesion and brain volumes are expressed in milliliters. Of the 42 patients with CIS, 33 presented with brain T2 lesions and 9 with spinal cord T2 lesions. Differences between the groups were tested using the χ2 (gender) test and Student t test. NA indicates not available.