Table 1:

Participant demographic characteristics, cognitive function, and MRI measures across diagnostic groups

	CNn = 97	MCIn = 65	Dementedn = 47	P Value
Demographic characteristics
Gender (M/F)	33 / 64	32 / 33	19 / 28	P = .15
African American	13.4%	13.8%	8.5%	—
Hispanic	38.1%	29.2%	25.5%	—
White	41.2%	47.7%	61.7%	—
Age (years)	74.1 ± 7.5	73.6 ± 7.2	76.5 ± 9.2	P = .13
Education (years)	12.0 ± 5.0	13.0 ± 5.4	11.0 ± 4.3	P = .09
RS (clinic/community)	14 / 83	30 / 35	27 / 20	P < .001
Cognitive performance
MMSE	27.9 ± 2.3^a	25.7 ± 3.7^b	21.1 ± 5.2^c	P < .001
Semantic	.16 ± .88^a	−.18 ± .90^a	−.71 ± .95^b	P < .001
Episodic	.05 ± .86^a	−.86 ± .63^b	−1.56 ± .61^c	P < .001
Executive	−.08 ± .69^a	−.49 ± .59^b	−.91 ± .80^c	P < .001
Spatial	.02 ± .86^a	−.23 ± .97^a	−.73 ± .97^b	P < .001
Brain MRI measures
GM	.47 ± .03^a	.45 ± .03^b	.43 ± .03^c	P < .001
WMH	.007 ± .008^a	.009 ± .009^a,b	.012 ± .016^b	P = .03
FA-CC	.90 ± .06^a	.88 ± .06^a	.85 ± .10^b	P = .003
FA-Cingulum	.90 ± .08^a	.88 ± .09^ab	.85 ± .15^b	P = .01
FA-Fornix	.78 ± .09^a	.74 ± .07^b	.71 ± .09^b	P < .001
FA-SLF-FP	.89 ± .06	.87 ± .08	.87 ± .09	P = .22
FA-UNC	.91 ± .07^a	.90 ± .08^ab	.88 ± .08^b	P = .03

Note:—Continuous variables (MRI measures, cognition scores, education years, and age) are presented as mean and SD; ethnicity data are presented as percentages across cognitive groups.
Group differences determined by simple ANOVA; group differences of character variables determined by χ square. FA, ratio of young adult FA value; GM, percentage of total cranial volume; MMSE, Mini Mental State Examination.
a,b,c Means with different superscripts indicate significant group differences after Tukey-Kramer adjustments, where P <.05 was considered statistically significant.