Standardized neuroimaging protocol used in study
| Pulse Sequence | Scan Parameters |
|---|---|
| T1WI 3-plane localizer | |
| Sagittal T1WI, FSE | TR/TE: 600 ms/minimum; FOV: 250 mm; 352 × 256; ST/gap: 5/0 mm; NEX: 1; ETL: 2; full echo |
| Axial T1WI, FSE | TR/TE: 425/20 ms; FOV: 220 mm; 352 × 224; ST/gap: 5 mm/0; NEX: 1; ETL: 2; full echo |
| Axial T2WI FLAIR | TR/TE: 9600/140 ms; FOV: 220 mm; 352 × 224; ST/gap: 5 mm/0; NEX: 1; full echo |
| Axial GRE | TR/TE: 635 ms/minimum; FOV: 220 mm; 320 × 224; ST/gap: 5 mm/0; NEX: 1; flip angle: 20o; full echo |
| Axial DWI, EPI | TR/TE: 8200 ms/minimum; FOV: 220 mm; 128 × 128; ST/gap: 5 mm/0; NEX: 1; no. of shots: 1; full echo |
| Axial T2WI FSE | TR/TE: 3167/85 ms; FOV: 220 mm; 416 × 256; ST/gap: 5 mm/0; NEX: 2; ETL: 23 |
| Axial T1WI FSE, postcontrast | TR/TE: 425/20 ms; FOV: 220 mm; 352 × 224; ST/gap: 5 mm/0; NEX: 1; ETL: 2; full echo |
| Sagittal 3D spoiled GRE (BRAVO), postcontrast | TR/TE/TI: 450 ms/minimum/450 ms; FOV: 307 mm; 256 × 256 × 136; ST: 1.2 mm; NEX: 1; flip angle: 15o |
| Dynamic contrast-enhanced perfusion MRI, gradient-echo EPI | TR/TE: 2000 ms/minimum; FOV: 240 mm; 129 × 96; ST/gap: 5 mm/0; NEX: 1; no. of shots: 1; flip angle: 60o |
| Axial multisection 1H-MRS | TR/TE: 2300/280 ms; FOV: 240 mm; 20 × 20; ST/gap: 15/3.5 mm; NEX: 1; 4 sections, interleaved. |
Note:—ETL indicates echo-train length; GRE, gradient-recalled echo; ST, section thickness.