Overview of the most frequent brain and spinal MRI abnormalities according to disease type
| Signal Alterations | Enlarged PVS | Hydrocephalus/Ventriculomegaly | Atrophy | Spinal Stenosis | |
|---|---|---|---|---|---|
| MPS I | |||||
| Hurler | +++ | +++ | +++ | ++ | ++ |
| Hurler/Scheie | ++ | ++ | ++ | + | ++ |
| Scheie | ++ | ++ | ++ | + | ++ |
| MPS II | +++ | +++ | +++ | +++ | + |
| MPS III | |||||
| IIIA | ++ | ++ | ++ | + | + |
| IIIB | ++ | ++ | + | +++ | – |
| IIIC | – | – | – | – | – |
| IIID | + | ± | + | – | |
| MPS IV | |||||
| IVA | ± | – | ± | – | +++ |
| IVB | ± | – | – | – | +++ |
| MPS VI | + | ++ | + | + | +++ |
| MPS VII | ++ | – | – | – | + |
| MPS IX | – | – | – | – | – |
Note:—+++ indicates a constant finding; ++, a frequent finding; +, a less frequent finding; ±, rare; –, not described in the literature to our knowledge.