Regions with DTI values significantly different from those of control subjects at each time point (T0–T4)
| Period | FA and MD | FA Only | MD Only |
|---|---|---|---|
| T0 (pre-HSCT) | CWM,a MGN, OR, POWM, SpCC | ATWM,a LGN, MeyLo, PLIC | DSCPa |
| T1 | CWM,a NAFWM,a SpCC | CST, LGN, MGN, MeyLo, OR, POWM | |
| T2 | CWM,a POWM, SpCC | LGN, MeyLo, NAFWM,a OR | PLIC |
| T3 | POWM, SpCC | CWM,a LGN, MeyLo, NAFWM,a OR | MGN |
| T4 | CWM,a MeyLo, OR, POWM, SpCC | LGN, BIC | MGN |
Note:—ATWM indicates anterior temporal WM; CST, corticospinal tract; CWM, cerebral WM; DSCP, decussation of the superior cerebellar peduncles; LGN/MGN, lateral/medial geniculate nuclei; MeyLo, Meyer loop; NAFWM, normal-appearing frontal WM; OR, optic radiations; PLIC, posterior limb of the internal capsule; POWN, parietooccipital WM; SpCC, splenium of the corpus callosum.
↵a Regions of normal intensity on FLAIR in all 8 patients with ALD at all 5 time points.