Pearson correlation coefficients (R²) for individual MRI biomarkers (top row) versus the LINCL score and biomarker combinations performed using PCA^{^a}

ADC	WM FA	GM T2	%CSF	NAA/Cr	PCA
0.62	0.40	0.25	0.70	0.63
X	X	X	X	X	0.70
X	X		X	X	0.75
X			X	X	0.76

Note:—X indicates that this specific MRI biomarker was included in that combination of PCA analysis to produce the R² quoted in the last column.
↵a Only the best 3 combinations are shown.