Comparison of clinical and MR imaging findings between patients with EBV-positive PCNSL and those with EBV-negative PCNSL
| EBV (+) | No. | EBV (−) | No. | P Value | |
|---|---|---|---|---|---|
| Clinical parameters | |||||
| Age (mean) (yr) | 57.8 | 10 | 57.1 | 45 | .872 |
| Sex (male/female) | 7/3 | 10 | 30/15 | 45 | .725 |
| Follow-up periods (wk) | 3–50 | 10 | 2–143 | 45 | N/A |
| Median progression (wk) | N/A | 10 | 58 | 45 | N/A |
| Conventional imaging | |||||
| Multiplicity (single/multiple) | 6/4 | 10 | 23/22 | 45 | .715 |
| Location (PV/lobar/both) | 1/6/3 | 10 | 22/12/11 | 45 | .122 |
| Shape (irregular/lobulating) | 2/8 | 10 | 27/18 | 45 | .067 |
| Necrosis (+/−) | 9/1 | 10 | 8/37 | 45 | .0001 |
| Hemorrhage (+/−) | 7/3 | 10 | 3/42 | 45 | <.0001 |
| Advanced imaging | |||||
| ADCsolid (mean) | (0.77 ± 0.15) × 10−3 mm2/s | 8 | (0.74 ± 0.27) × 10−3 mm2/s | 20 | .761 |
| rCBVmax (mean) | 2.69 ± 0.79 | 9 | 2.65 ± 0.81 | 20 | .715 |
| rCBVr (mean) | 1.82 ± 0.72 | 9 | 1.75 ± 0.86 | 20 | .729 |
| Cho/NAA ratio | 6.20 ± 8.28 | 6 | 8.11 ± 7.22 | 16 | .269 |
Note:—+ indicates positive; −, negative; N/A, not applicable; PV, periventricular.