Mean values for tissue segment volumes, MTR, MD (b = 1000 s/mm2), and MD (b = 3000 s/mm2) in selected ROIs
| Brain Region | Control Group | 6-OPRI Group | P Valueb |
|---|---|---|---|
| Right thalamus | |||
| WM (tv)a | 0.66 ± 0.07 | 0.57 ± 0.05 | .002 |
| MTR (%) | 40.6 ± 1.2 | 38.9 ± 1.1 | .002 |
| MD1K (×10−3mm2/s) | 0.81 ± 0.03 | 0.88 ± 0.05 | <.001 |
| MD3K (× 10−3mm2/s) | 0.63 ± 0.01 | 0.67 ± 0.03 | <.001 |
| Right caudate | |||
| GM (tv) | 0.74 ± 0.07 | 0.50 ± 0.08 | <.001 |
| MTR (%) | 37.6 ± 1.1 | 33.8 ± 2.2 | <.001 |
| MD1K (× 10−3mm2/s) | 0.79 ± 0.03 | 0.88 ± 0.10 | .001 |
| MD3K (× 10−3mm2/s) | 0.63 ± 0.02 | 0.64 ± 0.03 | NS |
| Right putamen | |||
| GM (tv) | 0.92 ± 0.12 | 0.60 ± 0.12 | <.001 |
| MTR (%) | 38.6 ± 1.0 | 36.8 ± 1.1 | .001 |
| MD1k (× 10−3mm2/s) | 0.78 ± 0.02 | 0.83 ± 0.07 | .008 |
| MD3k (× 10−3mm2/s) | 0.65 ± 0.01 | 0.63 ± 0.03 | .04 |
Note:—GM indicates gray matter; MD1k, mean diffusivity (b=1000 s/mm2); MD3k, mean diffusivity (b=3000 s/mm2); NS, not significant (p ≥0.1); tv, modulated tissue segment fractional volume. Values are mean ± SD over subject group of the individual ROI means.
↵a WM is reported here because the SPM8 segmentation routine classifies the thalamus as a predominantly WM structure.
↵b P values are reported for the Mann-Whitney U test.