Table 2:

Adjusted β coefficients^a of predictors of the overall perivascular space scores and by anatomic regions

	Overall Score		Perivascular Space Score by Anatomic Region
	Overall Score		Subcortical White Matter		Basal Ganglia		Infratentorial
	β Coefficient	P Value	β Coefficient	P Value	β Coefficient	P Value	β Coefficient	P Value
Age	0.01	.02	0.008	.15	0.01	.02	0.02	.19
Male sex	−0.11	.12	−0.21	.01	0.05	.52	−0.35	.08
Race
White	Ref		Ref		Ref		Ref
Black	0.004	.96	0.11	.37	−0.07	.51	−0.47	.12
Hispanic	−0.11	.17	−0.06	.57	−0.15	.10	−0.20	.40
Body mass index	−0.004	.53	−0.004	.61	−0.003	.64	−0.008	.63
Smoking
Never	Ref		Ref		Ref		Ref
Former	0.02	.35	0.05	.55	−0.05	.52	0.35	.07
Current	0.08	.78	0.14	.20	−0.04	.61	0.76	.001
Hypertension	0.17	.01	0.11	.20	0.20	.02	0.59	.008
Antihypertensive medications	−0.11	.09	−0.13	.13	−0.09	.24	−0.28	.24
Diabetes	0.03	.71	0.06	.51	−0.003	.96	−0.04	.88
Hypoglycemic medications	−0.18	.19	−0.19	.10	−0.03	.79	−0.31	.40
Hypercholesterolemia	−0.12	.21	0.01	.93	−0.14	.02	−0.16	.38
Cholesterol-lowering medications	−0.24	.02	−0.22	.08	−0.22	.08	−0.76	.04
History of cardiac disease	0.07	.32	−0.02	.81	0.15	.05	0.26	.23
Carotid plaque	0.22	<.001	0.29	<.001	0.16	0.02	0.22	.21

Note:—Ref indicates reference group.
↵a Coefficients were adjusted for all other demographic variables plus medications to treat hypertension, diabetes, and hypercholesterolemia.