Evolution of whole-brain and tissue-specific MRI measures during 5 years, split by progression status at 5 yearsa
| Sustained Disease Progression (mean) (SD) (median) | Stable Disease (mean) (SD) (median) | P Value | |
|---|---|---|---|
| T2-LV (No. patients) | 80 | 78 | |
| Absolute change | 2.8 (6.3) 1.6 | 2.3 (3.8) 1.0 | |
| % Change | 53.9 (66.7) 36.3 | 79.1 (156.4) 40.5 | .4 |
| Whole-brain (No. patients) | 82 | 80 | |
| % Change | −4.8 (3.4) −3.9 | −2.6 (2) −2.2 | <.0001 |
| Gray matter (No. patients) | 82 | 79 | |
| % Change | −5.3 (3.1) −4.5 | −3.8 (2.3) −4.1 | .003 |
| White matter (No. patients) | 82 | 79 | |
| % Change | −0.9 (3.4) −0.5 | 0.4 (3.1) 0.8 | .06 |
| Lateral ventricle volume, (No. patients) | 82 | 79 | |
| % Change | 26.7 (24.8) 22.6 | 14.9 (11.3) 13.4 | .02 |
| Cortical volume (No. patients) | 80 | 78 | |
| % Change | −5.4 (3.1) −4.9 | −3.8 (2.2) −4 | .001 |
Note:—T2-LV indicates T2-lesion volume.
↵a The difference between the groups was calculated using regression analysis adjusting for age, disease duration, and change of treatment status during the 5-year follow-up. The absolute volume changes are presented in milliliters. Variables with skewed distributions (% change in T2-LV and % change in LV) were transformed using Box-Cox transformations. The changes between baseline and follow-up scans for whole-brain, gray matter, white matter, lateral ventricle, and cortical volume were calculated using the direct-measurement technique; hence, no absolute but only percentage volume changes are available.