Effects of age, APOE ε4, and sex on rates of change in AD
| AD Measure | b0 | bCog | bEdu | bAge (SE; P) | bAPOE (SE; P) | bSex (SE; P) |
|---|---|---|---|---|---|---|
| Hippocampus | −2.80a | −0.06a | 0.03 | 0.06a (.03; .028) | −0.62 (.35; .08) | −0.49 (.30; .1) |
| Amygdala | −2.73a | −0.05 | 0.06 | 0.06a (.03; .043) | −0.91a (.36; .012) | −0.41 (.31; .2) |
| Entorhinal | −2.65a | −0.04 | −0.02 | 0.04a (.02; .045) | −0.43 (.25; .09) | −0.49a (.22; .025) |
| Inferior parietal | −1.68a | −0.06a | −0.03 | 0.15a (.02; <10−6) | −0.25 (.24; .3) | −0.69a (.21; .001) |
| Middle temporal | −2.48a | −0.10a | −0.05 | 0.17a (.02; <10−6) | −0.30 (.29; .3) | −0.88a (.25; .001) |
| Med-orbito-frontal | −0.96a | −0.02 | −0.02 | 0.05a (.02; .008) | 0.04 (.24; .9) | −0.64a (.21; .002) |
| Whole brain | −0.97a | −0.04a | −0.01 | 0.06a (.01; <10−6) | −0.19 (.14; .2) | −0.38a (.12; .002) |
| CDR-SB | 1.39a | – | 0.11a | 0.01 (.03; .8) | 0.27 (.33; .4) | 0.10 (.29; .7) |
| ADAS-Cog | 3.20a | – | 0.29 | −0.15 (.08; .069) | 1.25 (.98; .2) | 0.49 (.89; .6) |
| MMSE | −1.97a | – | −0.16 | 0.13a (.05; .007) | −0.20 (.57; .7) | 0.03 (.52; 1.0) |
Note:—See Table 2 for units and key.
↵a Values significant at P ≤ .05.
ROIs: N = 105; mean age = 75.74 years; mean ADAS-Cog = 18.49; mean years education = 14.83. Cognitive: N = 144; mean age = 75.99 years; mean years education = 14.70.