Characteristics of patients with CADASIL and healthy controls

Patients with CADASIL (n = 22)Healthy Controls (n = 29)P Value
Age (yr) (mean) (range)53.5 ± 11.1, 32.1–74.553.8 ± 11.0, 30.1–71.4.73
Male sex (No.) (%)11/22 (50%)15/29 (52%).88
Right-handed (No.) (%)22/22 (100%)28/29 (97%).99
Level of education (yr)11.7 ± 3.913.6 ± 3.5.08
MMSE (mean) (median) (range)28.5, 29, 25–3029.0, 29, 26–30.26
Brain volume in mm3 (mean)1017202 ± 1132331003640 ± 84340.64 (.61)a
Normalized GM peak (mean)0.30 ± 0.050.31 ± 0.05.48 (.45)a
Normalized WM peak (mean)0.59 ± 0.060.67 ± 0.09.001 (.001)a
Contrast between GM and NAWM (mean)1.35 ± 0.081.43 ± 0.04.001 (<10−5)a
White matter lesion volume, (mean) (median) (range) in mm397972.9, 76256.6, 7249.8–267095.1NA–
Lacunar lesion volume (mean) (median) (range) in mm3 (n = 14/22, 64%)b526.1, 290.1, 14.0–1974.7NA–
No. of microhemorrhages (mean) (median) (range) (n = 8/22, 36%)b6.5, 2.5, 1–32NA–

  • Note:—NA indicates not applicable; –, no test performed.

  • ↵a P value adjusted for age and sex.

  • ↵b In patients with such lesions (number given in parentheses).