Okuda RIS criteria13
MRI criteria
Ovoid, well-circumscribed, and homogeneous foci with or without involvement of corpus callosum. T2 hyperintensities measuring >3 mm in size fulfilling at least 3 of 4 Barkhof criteria14 for DIS, which are: 1) ≥9 lesions or ≥1 gadolinium-enhancing lesion, 2) ≥3 periventricular lesions, 3) ≥1 juxtacortical lesion, and 4) ≥1 infratentorial lesion. CNS white matter anomalies are not consistent with a vascular pattern.
No historical accounts of remitting clinical symptoms consistent with neurologic dysfunction. The MRI anomalies do not account for clinically apparent impairments in social, occupational, or generalized areas of functioning. The MRI anomalies are not due to the direct physiologic effects of substances (eg, drug abuse, toxic exposure) or a medical condition. Exclusion of individuals with MRI phenotypes suggestive of leukoaraiosis or extensive white matter pathology lacking involvement of the corpus callosum. The MRI anomalies are not better accounted for by another disease process.
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Swanton RIS criteria17
MRI criteria
DIS defined as presence of ≥1 T2 lesion in ≥2 of the following brain regions (periventricular, juxtacortical, and infratentorial) or in the spinal cord.
No historical accounts of remitting clinical symptoms consistent with neurologic dysfunction. The MRI anomalies do not account for clinically apparent impairments in social, occupational, or generalized areas of functioning. The MRI anomalies are not due to the direct physiologic effects of substances (eg, drug abuse, toxic exposure) or a medical condition. Exclusion of individuals with MRI phenotypes suggestive of leukoaraiosis or extensive white matter pathology lacking involvement of the corpus callosum. The MRI anomalies are not better accounted for by another disease process.
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