Summary of MRI and clinical characteristic of 7 patients diagnosed with BRRS

Patient No.	Sex	Age at MRI (y)	Macrocephaly	Mutation PTEN	Development	Physical Features	WM Cyst	Cyst Location
1	M	4	Yes	Yes	Autistic	Abdominal hemangioma	Yes	f,p,t
2	M	0.65	Yes	Yes	Delay	Café au lait spot, thyroid nodules, testicular hamartomas, rectal and gastric polyps	Yes	p
3	M	2.7	Yes	No protein	Autistic	Motor speech disorder	Yes	f,p
4	M	3.5	90th centile	No protein	Delay	Café au lait spot	Yes	p
5	M	2.6	Yes	No protein	Delay	Moles, thyroid nodules, intestinal polyps	Yes	p
6	M	7.7	Yes	No protein	Delay	Moles, thyroid nodules, intestinal polyps	Yes	p
7	M	7.7	Yes	Yes	Delay	Pigmentation of the glans penis, multiple thyroid nodules, and carcinoma	Yes	f,p