Tumor pathologic features by WHO grade, age, location, and rTBF

Tumor Pathologic FeatureWHO GradeMean AgeaTumor LocationrTBFb
High-grade tumors (III and IV) (n=21)
    Glioblastoma (4)IV13 ± 8.5Cerebrum3.70 ± 1.89
    Anaplastic astrocytoma (1)III11Cerebrum3.60
    CNS PNET (1)IV9Thalamus1.32
    Medulloblastoma (9)IV6.1 ± 3.7PF2.87 ± 1.74
    Primary malignant melanoma (1)IV12Cerebrum1.70
    Anaplastic ependymoma (2)III3 ± 2.8PF1.99 ± 0.39
    CNS ATRT (1)IV4Cerebrum1.67
    Choroid plexus carcinoma (1)III3 monthsLateral ventricle7.96
    DIPG (1)III7Pons1.70
Low-grade tumors (I and II) (n=32)
    Pilocytic astrocytoma (8)I9.4 ± 6.1Cerebrum (1), cerebellum (3), brain stem (4)1.05 ± 0.19
    Hypothalamic astrocytoma (1)II10Hypothalamus–third ventricle0.99
    Angiocentric glioma (1)I15Cerebrum0.94
    DNT (2)I5.5 ± 4.9Cerebrum0.89 ± 0.13
    OPG (4)I4.8 ± 1.5Optic chiasm0.80 ± 0.09
    Choroid plexus papilloma (3)I5.6 ± 3.5PF (2), lateral ventricle (1)1.13 ± 0.15
    Atypical choroid plexus papilloma (1)II2PF1.34
    Ganglioglioma (6)I6.2 ± 6.6Cerebrum (5), brain stem (1)1.45 ± 0.54
    Craniopharyngioma (4)I12.8 ± 4.3Suprasellar cistern0.99 ± 0.13
    Atypical meningioma (1)II8 monthsCerebrum1.60
    Ependymoma (1)II3PF1.82
Unspecified grade (n=1)
    DIPG (1)II–IV6Pons1.35
  • Note:—ATRT indicates atypical teratoid rhabdoid tumor; PF, posterior fossa; PNET, primitive neuroectodermal tumor.

  • a Age in years, unless otherwise specified.

  • b rTBF equals the averaged maximal rTBF values from 2 different ROIs within the solid tumor.