Table 1:

Details of included serial MRI studies

MRI ModalityPopulationTiming of MRI (wk)Main Findings
Structural conventionalDyet et al8119 Infants <30 wksSerialAbnormal outcomea at 18 mos was related to major destructive lesions, DEHSI, cerebellar hemorrhage, and posthemorrhagic ventricular dilation
Miller et al3989 Infants <34 wks32 + 37Abnormal outcome at 18 mosb was related to severity of WM injury, ventriculomegaly, and intraventricular hemorrhage on first (RR, 5.6) and second (RR, 5.3) MRIs
Tam et al40131 Infants <34 wks32 + 37Abnormal neurologic examination findings at 4.8 yrs were related to large and small cerebellar hemorrhage; OR for small hemorrhage was 5.0
DTIDrobyshevsky et al7024 Infants <32 wks30 + 36PDIb at 24 mos correlated to FA of the PLIC at 30 wks (r = 0.55), faster increase of FA/wk in internal capsule (r = −0.63), and occipital WM (r = −0.59)
Glass et al719 Infants <34 wks33 + 38FA of the optic radiation was correlated with visual-evoked-potential amplitude (r = 0.7) at 10.5 mos
VolumetricDubois et al8145 Infants <36 wks32 + 41Functional assessment at term was associated with inner cortical surface and sulcation index
Kapellou et al82 Rathbone et al83119 Infants <30 wksSerialGrowth of the cortical surface area was related to neurodevelopmental outcomea at 24 mos and full-scale IQ at 6 yrs
  • Note:—RR indicates relative risk; OR, odds ratio; PDI, Psychomotor Development Index.

  • a Griffiths Mental Developmental Scales.

  • b Bayley Scales of Infant Development.