HC (n = 110) | MS (n = 285) | RRMS (n = 210) | PMS (n = 75) | P Value | ||
---|---|---|---|---|---|---|
Age (y), mean (SD) median | 47.0 (12.9) 50 | 46.9 (8.2) 48 | 0.965 | 46.1 (8.5) 46 | 49.2 (6.5) 50 | .006* |
Sex, female, n (%) | 76 (69.1) | 206 (72.3) | 0.329 | 149 (70.9) | 57 (78) | .496 |
Disease duration (y), mean (SD) median | NA | 14.4 (9.1) 13 | 13.2 (8.8) 12 | 17.9 (9.2) 18 | <.001* | |
EDSS, mean (SD) median | NA | 3.4 (1.9) 3.0 | 2.6 (1.5) 2.5 | 5.4 (1.5) 6.0 | <.001* | |
T2-LV, mean (SD) median | 0.3 (1.2) 0 | 13.5 (16.1) 7.3 | <.001* | 11.0 (13.5) 6.7 | 20.4 (20.4) 13.2 | .001* |
T1-LV, mean (SD) median | 0 | 3.3 (6.5) 1.0 | NA | 2.7 (6.1) 0.8 | 5.1 (7.2) 1.7 | .037* |
T1-Gd-LV mean (SD) median | NA | 0.05 (0.02) 0 | NA | 0.06 (0.4) 0 | 0.01 (0.02) 0 | .046* |
Note:—EDSS indicates Expanded Disability Status Scale; LV, lesion volume; NA, not available; SD, standard deviation.
Statistical analysis among groups was performed with the Student t test, test, the Mann-Whitney U test and the χ2 test. All P values were corrected for multiple comparisons with use of Benjamini-Hochberg correction.
The volumes are expressed in milliliters.
↵* indicates significant P values (P < .05) after correction.