Regional analysis of GM volumea
| Region | GM Volume (% of TIV) | |||||||
|---|---|---|---|---|---|---|---|---|
| HC | MCI | AD | F2, 27 | Sig. | ||||
| Mean | SD | Mean | SD | Mean | SD | |||
| Temporal lobe | ||||||||
| Hippocampus R | .120b,d | .004 | .104c,d | .016 | .099b,c | .010 | 8.3 | <.005 |
| Hippocampus L | .105d | .005 | .096d | .016 | .075b,c | .012 | 15.3 | <.001 |
| Parahippocampal and ambient gyri R | .173d | .012 | .168 | .018 | .151c | .013 | 5.7 | <.01 |
| Parahippocampal and ambient gyri L | .180d | .008 | .173 | .022 | .158c | .015 | 4.2 | <.05 |
| Anterior TL lateral part R | .135 | .018 | .123 | .018 | .119 | .017 | 2.2 | NS |
| Anterior TL lateral part L | .118 | .015 | .111 | .016 | .101 | .016 | 2.8 | NS |
| Anterior TL medial part R | .272d | .022 | .251 | .025 | .227c | .035 | 6.6 | <.01 |
| Anterior TL medial part L | .254 | .028 | .241 | .029 | .210 | .046 | 3.9 | <.05 |
| Posterior TL R | 1.35 | .086 | 1.32 | .115 | 1.25 | .096 | 2.5 | NS |
| Posterior TL L | 1.32d | .086 | 1.26 | .136 | 1.18c | .119 | 3.4 | <.05 |
| Insula and cingulate gyri | ||||||||
| Insula R | .414d | .025 | .378 | .048 | .365c | .029 | 5.0 | <.05 |
| Insula L | .432d | .030 | .395 | .057 | .370c | .031 | 5.3 | <.05 |
| Anterior cingulate R | .272 | .027 | .270 | .030 | .282 | .019 | .49 | NS |
| Anterior cingulate L | .282 | .033 | .272 | .029 | .274 | .020 | .42 | NS |
| Posterior cingulate R | .261 | .029 | .264 | .017 | .266 | .023 | .09 | NS |
| Posterior cingulate L | .273 | .028 | .270 | .024 | .275 | .021 | .12 | NS |
| Frontal lobe | ||||||||
| Middle frontal gyrus R | 1.19 | .065 | 1.13 | .089 | 1.11 | .093 | 2.5 | NS |
| Middle frontal gyrus L | 1.13c | .063 | 1.08 | .119 | 1.02c | .091 | 3.3 | .05 |
| Medial orbitofrontal R | .184 | .013 | .159 | .042 | .156 | .035 | 2.3 | NS |
| Medial orbitofrontal L | .195 | .014 | .181 | .031 | .166 | .036 | 2.6 | NS |
| Subgenual anterior cingulate R | .039 | .005 | .036 | .015 | .046 | .016 | .01 | NS |
| Subgenual anterior cingulate L | .046 | .006 | .046 | .009 | .046 | .016 | .24 | NS |
| Parietal/occipital lobe | ||||||||
| Cuneus R | .271 | .031 | .246 | .051 | .243 | .064 | 1.0 | NS |
| Cuneus L | .292 | .029 | .273 | .043 | .257 | .063 | 1.4 | NS |
| Superior parietal lobe R | 1.04 | .111 | .866 | .265 | .853 | .217 | 2.4 | NS |
| Superior parietal lobe L | 1.02 | .089 | .977 | .095 | .847 | .211 | 4.2 | <.05 |
| Inferolateral parietal lobe R | 1.07 | .099 | 1.04 | .098 | 1.01 | .079 | 1.1 | NS |
| Inferolateral parietal lobe L | 1.07 | .086 | 1.04 | .114 | .968 | .080 | 2.6 | NS |
| Central structures | ||||||||
| Thalamus R | .186 | .019 | .177 | .024 | .180 | .024 | .50 | NS |
| Thalamus L | .199 | .026 | .199 | .026 | .194 | .022 | .01 | NS |
| Caudate R | .170 | .019 | .160 | .021 | .161 | .020 | .86 | NS |
| Caudate L | .160 | .029 | .157 | .026 | .153 | .015 | .16 | NS |
| Putamen R | .155 | .019 | .146 | .030 | .147 | .025 | .41 | NS |
| Putamen L | .167 | .019 | .160 | .028 | .162 | .022 | .29 | NS |
Note:—HC indicates healthy controls; NS, not significant; Sig., Significance; R, right; L, left; TL, temporal lobe; TIV, total intracranial volume.
↵a Superscript letters indicate significant pair-wise comparisons revealed by post hoc testing (Tamhane T2, P = .05).
↵b Significantly different from MCI.
↵c Significantly different from HC.
↵d Significantly different from AD.