Antiplatelet regimen timeline
| Observation Period | Intervention | Day 1 after intervention | Follow-Up Period | |||
|---|---|---|---|---|---|---|
| Delivery of the First Stent | During Intervention | 12:00 am | 4:00 am | 10:00 am | ||
| ASA 100 mg/day | Tirofiban (Aggrastat) i.v., | Multiplate test | Clopidogrel 300 mg p.o. | Tirofiban (Aggrastat) i.v., stopped | Multiplate test | 1) First 6 months clopidogrel 75 mg/day and ASA 100 mg/day |
| 1) loading dose, 0.4 μg/kg/min (30 min), | 1) 15 min after tirofiban start, | ASA 100 mg p.o. | ASA response? clopidogrel response? | 2) lifelong therapy ASA 100 mg/day | ||
| 2) maintenance dose, 0.1 μg/kg/min | 2) end of the intervention, tirofiban response? | |||||
Note:—p.o. indicates by mouth; i.v., intravenous.