Multivariable logistic regression analysis of factors independently associated with a poor 90-day outcome
| Independent Variable | Model 1a | P Value | Model 2b | P Value | Model 3c | P Value | Model 4d | P Value |
|---|---|---|---|---|---|---|---|---|
| Severe leukoaraiosise | 6.50 (2.11–20.06) | <.001 | 4.40 (1.22–15.74) | .023 | 6.03 (1.80–22.11) | .004 | 6.37 (1.83–12.18) | .004 |
| Admission NIHSS score | – | – | 1.08 (1.00–1.16) | .027 | 1.09 (1.01–1.17) | .023 | 1.08 (1.00–1.16) | .041 |
| Age (yr) | – | – | 1.03 (0.99–1.07) | .065 | 1.03 (1.00–1.07) | .028 | 1.03 (0.99–1.06) | .005 |
| LDL | – | – | 0.98 (0.97–1.00) | .057 | 0.98 (0.97–1.00) | .014 | 0.99 (0.97–1.00) | .064 |
| Creatinine level | – | – | – | – | 3.21 (0.78–13.19) | .105 | – | – |
| Poor recanalization | – | – | – | – | 3.72 (1.10–12.53) | .034 | 2.94 (0.84–10.21) | .089 |
| Parenchymal hemorrhage | – | – | – | – | – | – | 3.23 (1.01–10.37) | .049 |
Note:— – indicates not applicable; LDL, low-density lipoprotein. Factors that were not included in the final model iteration are omitted from the table. Data are odds ratios with 95% confidence intervals.
↵a Model 1, unadjusted.
↵b Model 2, adjusted for age, admission NIHSS score, atrial fibrillation, creatinine level, LDL, and random blood sugar (Hosmer-Lemeshow statistics: χ2 = 6.047, P = .642).
↵c Model 3, additionally adjusted for collateral grade, degree of recanalization, and time to recanalization (Hosmer-Lemeshow statistics: χ2 = 9.856, P = .275).
↵d Model 4, adjusted for model 3 plus the presence of parenchymal hemorrhagic transformation (Hosmer-Lemeshow statistics: χ2 = 3.418, P = .905).
↵e The association with outcome remained when leukoaraiosis, degree of recanalization, and collateral grade were entered as ordinal variables (P < .01).