Prevalence and odds ratios of CMBs depending on number of risk factorsa
| Diagnostic Group | 0 RFb Prevalence | 1 RF | 2 RF | 3 RF | ≥4 RF | ||||
|---|---|---|---|---|---|---|---|---|---|
| Prevalence | OR | Prevalence | OR | Prevalence | OR | Prevalence | OR | ||
| All patients (n = 1504) | 10 (31) | 18 (92) | 2.1 (1.4–3.3)d | 28 (105) | 3.8 (2.5–5.9)c | 35 (69) | 5.3 (3.3–8.5)c | 33 (35) | 4.8 (2.8–8.4)c |
| Subjective cognitive impairment (n = 385) | 8 (13) | 10 (13) | 1.2 (0.5–2.8) | 11 (6) | 1.3 (0.5–3.8) | 24 (7) | 3.6 (1.3–10.2)e | 20 (2) | 3.2 (0.6–17.2) |
| Alzheimer disease (n = 423) | 7 (4) | 26 (37) | 4.9 (1.7–14.6)d | 37 (47) | 8.2 (2.8–24.4)c | 33 (23) | 7.1 (2.3–22.2)d | 23 (7) | 3.4 (0.9–13.1) |
| Mild cognitive impairment (n = 418) | 7 (5) | 17 (24) | 2.8 (1.0–7.7)e | 22 (25) | 3.7 (1.3–10.3)e | 37 (21) | 7.8 (2.7–22.9)c | 35 (14) | 7.2 (2.2–21.3)d |
| Vascular dementia (n = 54) | 67 (4) | 50 (3) | 0.5 (0.04–6.1) | 58 (11) | 0.6 (0.1–4.7) | 58 (7) | 0.5 (0.1–4.8) | 64 (7) | 0.8 (0.1–7.1) |
Note:—RF indicates risk factors; OR, odds ratio of CMBs in all groups; Prevalence, prevalence of CMBs in all groups.
↵a Numbers are % (No.), odds ratio (95% CI). Logistic regression analysis was performed with CMBs (present/absent) as a dependent variable and number of risk factors as an independent variable. Risk factors were defined as hypertension, hyperlipidemia, diabetes, male sex, and age 65 years and older. The model was corrected for MRI field strength (1.5T/3T) and CMB sequence (T2*/SWI). In the risk factor groups, prevalence of CMBs (number of patients) is stated to the left and odds ratios for CMBs, to the right.
↵b Patients with zero risk factors were used as a reference.
↵c P < .001, significant after Bonferroni correction.
↵d P < .05, significant after Bonferroni correction.
↵e P < .05, significant before Bonferroni correction.