Univariate logistic regression analysis of good clinical outcome (mRS ≤ 2) on demographic and clinical factors and imaging parameters
| mRS ≤ 2 (n = 98), Favorable Outcome | mRS > 2 (n = 175), Poor Outcome | P Value | OR (95% CI) | |
|---|---|---|---|---|
| Age (yr) | 67 (57–78) | 76 (66–83) | <.001 | 0.96 (0.94–0.98) |
| NIHSS pre-rtPA (median, IQR) | 17 (12–21) | 9.0 (4–15) | <.001 | 0.86 (0.82–0.90) |
| Female sex | 42 (42.86) | 88 (50.29) | .23 | 1.35 (0.82–2.23) |
| SBP | 151 (138.5–173.5) | 155 (137–171.5) | .93 | 1.00 (0.99–1.01) |
| DBP | 81 (72.5–92) | 80 (70–90) | .26 | 1.01 (0.99–1.02) |
| Glucose (admission)a | 6.4 (5.4–7.3) | 6.4 (5.4–7.3) | .04 | 0.42 (0.17–0.92) |
| Risk factors | ||||
| Hypertension | 54 (55.10) | 118 (67.43%) | .04 | 0.59 (0.36–0.99) |
| Diabetes mellitus | 15 (15.31) | 38 (21.71) | .20 | 0.65 (0.33–1.24) |
| Hypercholesterolemia | 29 (29.59) | 68 (38.86) | .12 | 0.66 (0.39–1.12) |
| Coronary artery disease | 23 (24.3) | 42 (24) | .92 | 0.97 (0.54–1.73) |
| Atrial fibrillation | 29 (29.59) | 54 (30.86) | .82 | 0.94 (0.55–1.61) |
| Smoker | 22 (22.45) | 28 (16) | .18 | 1.52 (0.81–2.83) |
| Stroke | 1 (1.02) | 1 (0.57) | .68 | 1.79 (0.07–45.66) |
| Hyperdense sign | 48 (48.98%) | 101 (58.05) | .14 | 0.69 (0.42–1.14) |
| EIC | 84 (85.91) | 158 (90.29) | .25 | 0.65 (0.30–1.39) |
| ASPECTS (median, IQR) | 8 (6–9) | 7 (5–8) | .001 | 1.24 (1.09–1.42) |
| Clot burden score | 7 (6–9) | 6 (4–9) | .002 | 1.14 (1.05–1.25) |
| Collateral score | 2 (2–3) | 2 (1–3) | .02 | 1.46 (1.06–2.04) |
| CBV (median, IQR)a | 8.77 (2.5–24.09) | 25.14 (9.1–49.60) | <.001 | 0.58 (0.46–0.72) |
| CBF | 88.12 (44.7–122.1) | 104.17 (74.3–143.6) | <.001 | 0.99 (0.99–1.00) |
| MTT | 87.96 (43.2–125.9) | 105.4 (77.5–138.8) | <.001 | 0.99 (0.99–1.00) |
| Time and thrombolysis | ||||
| rtPA given (No. of the patients) | 80 (81.63%) | 139 (79.43%) | .66 | 1.15 (0.62–2.20) |
| rtPA dose (mg) | 64.0 (50–73) | 62.0 (54–72) | .94 | 1.00 (0.98–1.02) |
| Onset to CT (min) (median, IQR)a | 102.0 (74–151) | 105.0 (80.5–141.5) | .73 | 1.08 (0.68–1.72) |
| Onset to rtPA (min) (median IQR) | 145 (120–179) | 146 (126–175) | .70 | 1.00 (1.00–1.01) |
| Outcome | ||||
| Recanalization | 119 (55.35%) | 33 (61.1%) | <.001 | 3.58 (2.09–6.30) |
| Hemorrhagic transformation | 28 (30.43%) | 78 (48.75%) | .004 | 0.46 (0.26–0.78) |
| NIHSS improves >3 in 24 hours | 101 (46.3%) | 27 (49%) | .20 | 1.38 (0.84–2.27) |
| SPAN-100-positive | 6 (6.12%) | 49 (28%) | <.001 | 0.17 (0.06–0.38) |
Note:—EIC indicates early ischemic changes.
↵a Natural log-transformation was applied for normalizing the distribution.