Demographic and clinical characteristics of healthy controls and patients with active, remitted, and cured CSa
| Healthy Controls | Patients with Active CS | Patients with Remitted CS | Patients with Cured CS | F/χ2 | P Value | |
|---|---|---|---|---|---|---|
| Age (yr) | 42.3 ± 10.4 | 41.9 ± 8.7 | 47.1 ± 10.0 | 41.4 ± 10.0 | 5.9 | NS |
| Sex (M/F) | 6:29 | 1:7 | 1:6 | 4:16 | 0.3 | NS |
| Years of education | 13.5 ± 3.4 | 14.4 ± 3.0 | 12.9 ± 2.3 | 13.4 ± 3.1 | 0.3 | NS |
| 24-Hour urinary free cortisol | 133 ± 52 | 543 ± 307 | 152 ± 74 | 122 ± 75 | 26.3 | <.001b |
| Smoking status (nonsmoker/smoker/ex-smoker) | 12/12/11 | 7/1/0 | 2/4/1 | 9/5/6 | 10.4 | NS |
| Disease duration (mo) | NA | 77.6 ± 77.4 | 44.6 ± 21.9 | 64.6 ± 34.0 | 0.99 | NS |
| Origin (pituitary/adrenal/ectopic/AIMAH) | NA | 5/3/0/0 | 3/2/1/1 | 17/2/0/0 | 10.8 | NS |
| Hypertension (no/yes) | 35/0 | 4/4 | 3/4 | 13/7 | 20.9 | <.001c |
| Hypercholesterolemia (no/yes) | 31/4 | 7/1 | 7/0 | 17/3 | 1.2 | NS |
| Hypertriglyceridemia (no/yes) | 29/6 | 6/2 | 3/4 | 9/11 | 10.5 | .015d |
| Central obesity (no/yes) | 25/10 | 2/6 | 0/7 | 9/11 | 15.6 | .001e |
| Body mass indexg (no/overweight/obesity) | 22/11/2 | 2/5/1 | 1/3/3 | 8/9/3 | 12.6 | .049f |
Note:—NS indicates not significant; AIMAH, ACTH-independent macronodular adrenal hyperplasia.
↵a Data are expressed as mean ± SD.
↵b Healthy controls vs active CS (<.001); active CS vs remitted CS (<.001); active CS vs cured CS (<.001).
↵c Healthy controls vs active CS (<.001); healthy controls vs remitted CS (<.001); healthy controls vs cured CS (<.001).
↵d Healthy controls vs remitted CS (.043); healthy controls vs cured CS (.006).
↵e Healthy controls vs active CS (.015); healthy controls vs remitted CS (.001).
↵f Healthy controls vs remitted CS (.015).
↵g Body mass index: normal, ≤25; overweight, 25–30; obesity, >30.