Table 1:

Demographic, clinical, and MRI lesion and brain volumetric measures in patients with CIS over a 48-month period (n = 210)^{^a}

Measure	Patient Data
No. (%) female	139 (66)
Age at onset, y	28.7 ± 7.9
Time to baseline, days	81.9 ± 23.7
EDSS at baseline^{^b}	1.7 ± 0.7; 1.5 (0.0–3.5)
EDSS at 48 mo^{^b}	1.8 ± 0.9; 1.5 (0.0–6.5)
Cumulative no. of
Total new T2 lesions	7.7 ± 14.4; 3.0
New T2 lesions	5.8 ± 10.7; 2.0
Newly enlarging T2 lesions	1.9 ± 4.6; 0.0
Cumulative no. of new CE lesions	1.5 ± 6.1; 0.0
T2 lesion volume absolute change, mL	−0.08 ± 3.6; −0.1
CE lesion volume absolute change, mL	−0.07 ± 0.3; 0.0
WB volume, % change	−2.5 ± 2.1; −2.0
GM volume, % change	−2.3 ± 2.3; −2.0
WM volume, % change	−1.7 ± 2.1; −1.4
Cortical volume, % change	−2.8 ± 2.2; −2.6
Lateral ventricle volume, % change	16.9 ± 14.2; 14.3
Total normalized SDGM volume, % change	−3.6 ± 3.6; −3.1
Thalamic volume, % change	−4.6 ± 4.2; −4.0

Note:—WB indicates whole brain.
↵a Unless otherwise indicated, all data are reported as mean ± standard deviation; median.
↵b Data in parentheses are ranges.